This volume is based on a highly successful conference dedicated to "Perinatal brain damage:from pathogenesis to neuroprotection". Neonatologists, paediatricians, paediatric neurologists,obstetricians, basic researchers involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication.The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup and treatment.The most authoritative basic researchers, clinicians, and specialists in the field of neuroimaging, provide chapters on recent clinical advances.

A subject of particular importance is the neurological vulnerability of the preterm infant, which also touches on ethical aspects of the care of high-risk preterm babies and those born from multiple pregnancies. A particularly original session focuses on cerebral white matter and the many issues related to this crucial part of the developing brain. Experts also deal with cerebral visual impairment, motor development, cognitive function, and the mechanisms underlying the neuronal plasticity of the infant's brain. Concepts of neuroprotection are also outlined, based on pharmacological agents tested on experimental animals and the best drugs used to treat neonatal convulsions.


  • Neurotransmitters in the brain
  • Brain neuroreceptors: the molecular basis of drug action
  • Multiple types of programmed cell death and their relevance to perinatal brain damage
  • Prenatal diffusion MRI characterization of fetal brain oedema
  • Intrauterine growth restriction and neurological damage
  • Fetal cytomegalovirus infection: the brain as a window in the establishment of the prognosis
  • Perinatal brain damage
  • Is intensive care for all very immature babies justified?
  • Twins and triplets: relative effect of plurality and prematurity on neurological outcome
  • Cerebral ischaemia: still a plausible pathway to white matter injury in the preterm infant?
  • Oxidative stress in the developing brain
  • Infection/inflammation - a complex hot topic in perinatal brain white matter damage aetiology
  • White matter diseases of prematurity
  • Maternal and infant characteristics associated with perinatal arterial stroke in the preterm infant
  • Neonatal arterial ischaemic stroke
  • Neonatal cerebral sinovenous thrombosis
  • The spectrum of visual disorders in children with perinatal brain lesions: long term effects
  • Early predictors of cognitive development in very low birth weight children
  • The Neuronal Group Selection Theory: a framework to understand typical and atypical motor development
  • Brain plasticity in newborn infants with brain lesions: the role of brain MRI
  • Perinatal brain damage: from pathogenesis to neuroprotection
  • Caring for the preterm infant: earliest brain development and experience
  • Neonatal seizures: monitoring and treatment
  • Therapeutic approaches to psychomotor delay


Editeur : John Libbey

Auteur(s) : Luca A. Ramenghi, Philippe Evrard, Eugenio Mercuri

Collection : Mariani Foudation Paediatric Neurology

Publication : 4 décembre 2008

Edition : 1ère édition

Intérieur : Noir & blanc

Support(s) : Text (eye-readable) [PDF]

Contenu(s) : PDF

Protection(s) : Marquage social (PDF)

Taille(s) : 4,1 Mo (PDF)

Langue(s) : Anglais

Code(s) CLIL : 3165

EAN13 Text (eye-readable) [PDF] : 9782742010226

EAN13 (papier) : 9782742007233

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