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A "Generalized seizure" corresponds to an ictal manifestation whose initial semeiology indicates, or is consistent with, more than minimal involvement of both cerebral hemispheres. A network is a functionally and anatomically connected set of cortical and subcortical brain regions in which activity in any one part affects activity in all others. A system is a group of independent but interrelated elements (networks) comprising a unified whole. A considerable amount of evidence supports the existence of specific cortical and subcortical networks in the genesis, expression and control of generalized seizures. Animal and human data suggested that the so-called generalized seizures involve selective networks while sparing others. A greater understanding of those systems and networks, thoroughly debated in this book, will ultimately lead to improved targeted therapies for so-called generalized epilepsies.


  • Foreword
  • Workshop participants
  • Generalized seizures and epilepsies: a bilateral "focal" dysfunction?
  • Tonic seizures and brainstem systems
  • Absence seizures and cortico-thalamic systems
  • Myoclonic seizures and the frontal lobe
  • Primary versus Secondary Tonic-clonic seizures
  • The "cortical" and "centrencephalic" theories revisited
  • Phenomenology versus networks: clinical consequences
  • Concluding remarks


Editeur : John Libbey

Auteur(s) : Edouard Hirsch, Frederick Andermann, Patrick Chauvel, Jerome Engel, Fernando Lopes da Silva, Hans O. Lüders

Collection : Progress in Epileptic Disorders

Publication : 28 septembre 2006

Edition : 1ère édition

Intérieur : Noir & blanc

Support(s) : Text (eye-readable) [PDF]

Contenu(s) : PDF

Protection(s) : Marquage social (PDF)

Taille(s) : 3,8 Mo (PDF)

Langue(s) : Anglais

Code(s) CLIL : 3165

EAN13 Text (eye-readable) [PDF] : 9782742008810

EAN13 (papier) : 9782742006212

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