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Generalized Seizures: From clinical phenomenology to underlying systems and networks



A "Generalized seizure" corresponds to an ictal manifestation whose initial semeiology indicates, or is consistent with, more than minimal involvement of both cerebral hemispheres. A network is a functionally and anatomically connected set of cortical and subcortical brain regions in which activity in any one part affects activity in all others. A system is a group of independent but interrelated elements (networks) comprising a unified whole. A considerable amount of evidence supports the existence of specific cortical and subcortical networks in the genesis, expression and control of generalized seizures. Animal and human data suggested that the so-called generalized seizures involve selective networks while sparing others. A greater understanding of those systems and networks, thoroughly debated in this book, will ultimately lead to improved targeted therapies for so-called generalized epilepsies.


  • Foreword
  • Workshop participants
  • Generalized seizures and epilepsies: a bilateral "focal" dysfunction?
  • Tonic seizures and brainstem systems
  • Absence seizures and cortico-thalamic systems
  • Myoclonic seizures and the frontal lobe
  • Primary versus Secondary Tonic-clonic seizures
  • The "cortical" and "centrencephalic" theories revisited
  • Phenomenology versus networks: clinical consequences
  • Concluding remarks

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  • eBook [PDF]

    Pdf PDF (Generalized Seizures: From clinical phenomenology to underlying systems and networks), format 175 x 250, 337 pages
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  • Caractéristiques

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